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Mouse monoclonal antibody Anti-Human MXI1
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| Expression of the c-myc gene, which produces an oncogenic transcription factor, is
tightly regulated in normal cells but is frequently deregulated in human cancers.
The protein encoded by this gene is a transcriptional repressor thought to
negatively regulate MYC function, and is therefore a potential tumor suppressor.
This protein inhibits the transcriptional activity of MYC by competing for MAX,
another basic helix-loop-helix protein that binds to MYC and is required for its
function. Defects in this gene are frequently found in patients with prostate tumors.
Three alternatively spliced transcripts encoding different isoforms have been
described. Additional alternatively spliced transcripts may exist but the products of
these transcripts have not been verified experimentally.[NCBI Entrez Gene Summary] |
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Western blot analysis of immunized recombinant protein, using anti-MXI1 monoclonal antibody.
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids. |
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| Antibody Concentration |
100 μg/ml (1.0 ml) |
| Host Species |
Human |
| Preparation |
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Sterility |
Filtered through a 0.22 μm membrane. |
| Alternate Names |
MAD2, MXD2, MXI, MGC43220 |
| Accession No. |
BC012907 |
| Purchase |
Ordering information
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| Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off . |
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FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
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