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Mouse monoclonal antibody Anti-Human BIN1
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| This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of
which was initially identified as a MYC-interacting protein with features of a tumor
suppressor. Isoforms that are expressed in the central nervous system may be
involved in synaptic vesicle endocytosis and may interact with dynanim,
synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and
ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate
a caspase-independent apoptotic process. Studies in mouse suggest that this gene
plays an important role in cardiac muscle development. Alternate splicing of the
gene results in ten transcript variants encoding different isoforms. Aberrant splice
variants expressed in tumor cell lines have also been described.[NCBI Entrez Gene Summary] |
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Western blot analysis of immunized recombinant protein, using anti-BIN1 monoclonal antibody.
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids. |
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| Antibody Concentration |
100 μg/ml (1.0 ml) |
| Host Species |
Human |
| Preparation |
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Sterility |
Filtered through a 0.22 μm membrane. |
| Alternate Names |
AMPH2, AMPHL, SH3P9, MGC10367, DKFZp547F068 |
| Accession No. |
NM_139343 |
| Purchase |
Ordering information
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| Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off . |
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FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
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