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Mouse monoclonal antibody Anti-Human TAF4
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| Initiation of transcription by RNA polymerase II requires the activities of more than
70 polypeptides. The protein that coordinates these activities is transcription factor
IID (TFIID), which binds to the core promoter to position the polymerase properly,
serves as the scaffold for assembly of the remainder of the transcription complex,
and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding
protein (TBP) and a group of evolutionarily conserved proteins known as TBPassociated
factors or TAFs. TAFs may participate in basal transcription, serve as
coactivators, function in promoter recognition or modify general transcription
factors (GTFs) to facilitate complex assembly and transcription initiation. This gene
encodes one of the larger subunits of TFIID that has been shown to potentiate
transcriptional activation by retinoic acid, thyroid hormone and vitamin D3
receptors. In addition, this subunit interacts with the transcription factor CREB,
which has a glutamine-rich activation domain, and binds to other proteins
containing glutamine-rich regions. Aberrant binding to this subunit by proteins with
expanded polyglutamine regions has been suggested as one of the pathogenetic
mechanisms underlying a group of neurodegenerative disorders referred to as
polyglutamine diseases.[NCBI Entrez Gene Summary] |
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Western blot analysis of immunized recombinant protein, using anti-TAF4 monoclonal antibody.
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids. |
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| Antibody Concentration |
100 μg/ml (1.0 ml) |
| Host Species |
Human |
| Preparation |
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Sterility |
Filtered through a 0.22 μm membrane. |
| Alternate Names |
TAF2C, TAF4A, TAF2C1, FLJ41943, TAFII130, TAFII135 |
| Accession No. |
NM_003185 |
| Purchase |
Ordering information
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| Caution must be taken to avoid contact with skin or eyes. In such a case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention immediately. Wear appropriate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful. The vial is prone to fall over. Use caution, especially when the lid is off . |
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FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.
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